Phospholipase C-δ1 Is Activated by Capacitative Calcium Entry That Follows Phospholipase C-β Activation upon Bradykinin Stimulation
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چکیده
منابع مشابه
Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells.
Several receptors, including those for AVP (Arg8-vasopressin) and 5-HT (5-hydroxytryptamine), share an ability to stimulate PLC (phospholipase C) and so production of IP3 (inositol 1,4,5-trisphosphate) and DAG (diacylglycerol) in A7r5 vascular smooth muscle cells. Our previous analysis of the effects of AVP on Ca2+ entry [Moneer, Dyer and Taylor (2003) Biochem. J. 370, 439-448] showed that arac...
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ates rapid Ca store release through the activation of InsP3 receptors (IP3R) in the endoplasmic reticulum (ER) membrane (Berridge et al., 2000). Following this initial Randen L. Patterson,1,6 Damian B. van Rossum,2,6 Diana L. Ford,2 Kenneth J. Hurt,1 Sun Sik Bae,3 Pann-Ghill Suh,3 Tomohiro Kurosaki,4 Ca store-release, external Ca enters through plasma Solomon H. Snyder,1,5 and Donald L. Gill2 m...
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Phospholipase C (PLC) enzymes convert phosphatidylinositol-4,5-bisphosphate into the second messengers diacylglycerol and inositol-1,4,5-triphosphate. The production of these molecules promotes the release of intracellular calcium and activation of protein kinase C, which results in profound cellular changes. The PLCβ subfamily is of particular interest given its prominent role in cardiovascula...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.37.26127